PRELIMINARY PROGRAM
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9:00-16:00 Pre-conference Workshops 9:00 – 10:30 Academic Workshops (Part I) – Parallel Sessions
A. An academia/industry Xchange program for early career scientists, for the benefit of all – is the Frontiers vision feasible?
Organized by ESACT Frontiers Group
B. Analytical strategies for improved product characterization and process understanding
Organized by ACTIP – Animal Cell technology Industrial Platform
C. Single Cell Omics
Organized by Colin Clarke (NIBRT) and Antonio Roldão (iBET)10:30 – 12:00 Sponsored Symposium (Part I) – Parallel Sessions
sA. Symposium Organized by Sartorius
sB. Symposium Organized by Advanced Instruments LLC
sC. Sponsored Symposium Organized by Berkeley Lights12:00-13:00 Light Lunch Break 13:00 – 14:30 Academic Workshops (Part II) – Parallel Sessions
D_-Academic_workshop_Academic_Industry_Partnerships.pdf
Organized by Barry Buckland (UCL & BiologicB), Manuel Carrondo (iBET) and Carlos Guzman (HZI)
E. Extracellular vesicles – from basic biology to production of EVs as novel therapeutics
Organized by Johannes Grillari (Boku) and Mario Gimona (Paracelsus Medical Univ Salzburg)
F. How to develop perfusion processes?
Organized by Veronique Chotteau (AdBIOPRO & KTH) and Yvonne Genzel (Instituto Max Plank)14:30 – 16:00 Sponsored Symposium (Part II) – Parallel Sessions
sD. Symposium Organized by Cytiva
sE. Symposium Organized by Merck
sF. Sponsored Symposium Organized by Bristol Myers Squibb16:30 - 17:00 ESACT 2022 Opening Session 17:00-18:00 ESACT Innovation Award Lecture
Presented by Terry Papoutsakis, Chair of the ESACT Innovation Award
Committee (ESACT Honorary Member & University of Delaware, USA)
ESACT Innovation Award Committee is pleased to present the 2022 awardees:
For innovation in automated cell cultures technologies to support the development of biotherapeutics
Richard Wales and Neil Bargh18:00 – 19:30 Scientific Session: Bio breakthroughs
Chairs:
Luís Almeida, CNC Univ de Coimbra, Portugal
Laura Cervera, Univ Autònoma Barcelona, Spain
INV 1 - Title TBA
Manny Otero, Tunstone, United States
INV 2 - Innovating the Manufacturing of Human Mesenchymal Stromal Cells (MSC) and MSC-derived Products through Bioengineering
Claudia Lobato da Silve, IBB, IST, Univ de LSiboa, Portugal
O 1 - Preservation of critical quality attributes in 3D bioprinted cell-based structures by using natural hydrogels
Joaquim Vives, Banc de Sang i Teixits, Spain
O 2 - Turning an old medicine into a new therapeutical candidate: from erythropoietin to a novel hyperglycosylated, non-erythropoietic but neuroprotective analogue
Marcos Oggero, UNL, CONICET, FBCB, Centro Biotecnológico del Litoral/BioSynaptica SA, Argentina
O 3 - Systems-level discovery of quality attributes and candidate pathways for optimized production of human pluripotent stem cell-derived cardiomyocytes
Aaron Simons, NSF ERC for Cell Manufacturing Technologies (CMaT), United States
O 4 - Human stem-cell based models to study innate immunity and neuroinflammation in the central nervous system
Catarina Gomes, iBET, Instituto de Biologia Experimental e Tecnológica, Portugal
O 5 - Manipulating exosome biogenesis to enhance productivity of recombinant cell lines producing engineered exosome therapeutics
Shelly Martin, Codiak BioSciences, United States19:30 – 21:00 Exhibitors Reception at the Exhibition Hall -
9:00 - 10:00 Keynote Lecture
Botond Roska, Institute of Molecular and Clinical Ophthalmology Basel (IOB), Switzerland
Restoring vision using optogenetic therapy10:00 - 10:35 Poster Student Highlights
H1 - 3D Bioprinted Cellular Structures for Universal Production of Therapeutics
Laura Chastagnier, 3d.Fab – ICBMS, France
H2 - Semi-continuous propagation of influenza A virus and its defective interfering particles: Analyzing the dynamic competition to select antiviral candidates
Lars Pelz, Max Planck Institute for Dynamics of Complex Technical Systems, Germany
H3 - Extracellular Vesicles packaging and delivery of silencing sequences to alleviate a brain disorder
David Rufino-Ramos, CNC - Center for Neuroscience and Cell Biology of University of Coimbra, Portugal
H4 - Single-cell and Bulk RNA sequencing of insect Sf9 cells during rAAV production
Nikolaus Virgolini, iBET - Instituto de Biologia Experimental e Tecnológica, Portugal
H5 - Reverse genetics for Influenza A virus to generate genetically engineered defective interfering particles for antiviral treatment and vaccination
Tanya Dogra, Max Planck Institute for Dynamics of Complex Technical Systems, Germany
H6 - Investigating “Difficult-to-Express” mAb Frameworks in Transient and Site-Specific Integration-Based CHO Expression Systems
Alana C. Szkodny, University of Delaware, United States
H7 - Artificial miRNAs allow stepwise adjustment of core-fucosylation in CHO cells
Patrick Schlossbauer, Biberach University of Applied Sciences, Germany
H8 - Raman spectroscopy for monitoring of amino acids and antibody glycosylation in high cell density perfusion culture
Hubert Schwarz, Competence Centre for Advanced BioProduction Continuous Processing (AdBIOPRO), Royal Institute of Technology (KTH), Sweden
H9 - Lectin-aided flow cytometry reveals a close correlation between cell surface and mAb glycosylation
Mina Ghahremanzamaneh, School of Chemical and Bioprocess Engineering, University College Dublin, Republic of Ireland
H10 - Development of novel fast-growing Chinese hamster lung (CHL)-YN cells in serum-free fed-batch for monoclonal antibody production
Puriwat Sukwattananipaat, Graduate School of Engineering, Osaka University, Japan
H11 - Downstream process design and optimization of GAG HIV-1 based Virus-Like Particles
Elianet Lorenzo Romero, Universitat Autònoma de Barcelona, Spain10:35 - 11:00 Coffee Break at Exhibition 11:00 – 12:30 Scientific Session: Data, Data, Data: how to get it and how to use it
Chairpersons:
Mike Betenbaugh, John Hopkins Univ, USA
Damian Marshal, Achilles Therapeutics UK limited, UK
INV 3 - What can extracellular data tell us about intracellular pathways?
Cleo Kontoravdi, Imperial College London, United Kingdom
INV 4 - Bioprocessing in the Digital Age: from Process Models, through the Integration of Machine Learning, to Digital Twins
Alessandro Butté, DataHow AG, Switzerland
O 6 – Biomarker identification for in silico performance prediction of CHO cell lines expressing complex therapeutic Abs
Stella Papadaki, Roche Diagnostics GmbH, Germany
O 7 – On Digital Bioprocessing and Manufacturing Intelligence: Application of Process Analytical Technology and data analytics for upstream process development and intensification
Ricardo Suarez Heredia, University College London/University of Cambridge/Merck KGaA, United Kingdom
O 8 – Bioprocess digital twins for biomanufacturing 4.0
Dong-Yup Lee, SungKyunKwan University, Korea (South, Republic of)12:30 - 14:30 Lunch at Lunch Hall Dessert and coffee (will be served at Exhibition Hall) 14:30-16:00 Poster Session I (at Exhibition Hall) 16:00 – 17:30 Scientific Session: Beyond Evolution
Chairpersons:
Martin Fussenegger (ETH, Switzerland)
Nick Timmins (Artisan Bio, USA)
INV 5 - CAR T-cell immunotherapy of solid tumours: Parallel learning from the clinic and lab
John Maher King´s College London, United Kingdom
O 9 – Blueprint from nature: Multi-omics comparison of CHO and plasma cells unveils novel cell engineering targets to improve productivity
Nikolas Zeh, Boehringer Ingelheim Pharma GmbH, Germany
O 10 – Enabling large therapeutic gene delivery: improving dual AAV vector-intein mediated systems
Mariana Ferreira, ITQB NOVA & iBET, Portugal
O 11 – Theranostic cells for detection and counteraction of infections by rewiring cellular host defense pathways
Dagmar Wirth, Helmholtz Centre for Infection Research, Germany
O 12 – Viral protease-based molecular switches for drug discovery and synthetic biology applications
Nik Franko, ETHZ, Switzerland
Flash 1 – Expanding The Design Space of Synthetic Promoters for CHO Cell Engineering Using Next-Generation Sequencing
Adrian Bourke, University of Sheffield, United Kingdom
Flash 2 – Multiplexed engineering CHO cells to produce recombinant IgGs with desirable N-glycans via targeted integration
Nguyen Tran Bich Ngan, Bioprocessing Technology Institute, A*STAR, Singapore17:30 - 18:00 Coffee Break at Exhibition 18:00 – 19:30 Scientific Session: Molecular Cell Surgery
Chairpersons:
Isabelle Rivière, Memorial Sloan Kettering Cancer Center, USA
Nicole Borth, BOKU, Austria
INV 6 - Turning Genes into Medicines: Prospects and Problems in Development of a Novel Class of Therapeutics
Kathy High, AskBio, Therapeutics, United States
INV 7 - Guiding mRNA-LNP drug products from early R&D programs to the market – Scale up and production of mRNA LNPs
Andreas Wagner, Polymun Scientific, Austria
O 13 – Repairing the repairers: Stabilizing the CHO genome and protein production by editing DNA repair
Nathan Lewis, University of California, San Diego, United States
O 14 – Influenza A virus-derived defective interfering particles for antiviral treatment
Sascha Kupke, Max Planck Institute for Dynamics of Complex Technical Systems, Germany
O 15 – An arrayed CRISPR screen reveals Myc depletion to increase productivity of difficult-to-express complex antibodies in CHO cells
Niels Bauer, Roche Diagnostics GmbH, Germany
Flash 3 – Engineered nucleases targeting the ATXN3 gene for the therapy of Machado-Joseph disease
Sara Lopes, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal
Flash 4 – Rational development of recombinant CHO cells based on histone analysis: Identification and experimental validation of stable integration sites
Oliver Hertel, Bielefeld University, Germany19:30-21:00 Poster Viewing plus drinks (at Exhibition Hall) -
9:00 - 10:00 Keynote Lecture
Hildegard Büning, Hannover Medical School, Germany
Gene Therapy - a new class of medicine10:00 - 10:30 Selected Flash Presentations Session
Flash 5 – 4-1BB and 4-1BBxOX40 bispecific Anticalin®-based payloads to armor cellular immunotherapies for effective localized immune cell stimulation
Janet Peper-Gabriel, Pieris Pharmaceuticals GmbH, Germany
Flash 6 – Culture of Pluripotent Stem Cells and Derivation of Organoids using Droplet Microfluidics
Sebastien Sart, Institut Pasteur, France
Flash 7 – Augmented decision making for cell culture process development: from data traceability & accessibility to process modelling
Wolfgang Paul, Upstream Process Sciences Biotech Sciences, UCB Pharma S.A., Belgium
Flash 8 – Found in translation: Microproteins are a new class of potential host cell impurity in mAb drug products
Colin Clarke, NIBRT, Republic of Ireland
Flash 9 – Using a cell receptor knock-out strategy to enable stable expression of cytotoxic envelope glycoproteins for lentiviral vector production
Rodrigo Nogueira, iBET- Instituto de Biologia Experimental e Tecnológica, Portugal
Flash 10 – Endogenous BiP reporter system for simultaneous identification of ER stress and antibody production in Chinese hamster ovary cells
Jae Seong Lee, Ajou University, Korea (South, Republic Of)10:30 - 11:00 Coffee Break at Exhibition 11:00 – 12:30 Scientific Session: Adaptive manufacturing: engineering quality into your process (part I)
Chairpersons:
Anne Tolstrup, AbtBioConsult, Denmark
Laura Palomares, IBT-UNAM, Mexico
INV 8 - The Application of Mechanistic Models Combined with Statistical Approaches Including Multivariate Visualization and Bayesian Methods to Enable Rapid Process Understanding
Gene Schaefer, NIIMBL, United States
O 16 – Next-gen glycoengineering: combining cellular and metabolic engineering to fine-tune mAb β1,4 galactosylation
Apostolos Tsopanoglou, University College Dublin, Republic of Ireland
O 17 – Knowing more from less: a microfluidic toolbox for at-line monitoring of bioprocesses
Inês Pinto, Science for Life Laboratory & KTH Royal Institute of Technology, Sweden
O 18 – Accurate identification of transgene integration sites and their structure by Cas9 targeted nanopore sequencing in CHO cells
Klaus Leitner, Austrian Centre of Industrial Biotechnology (acib), BOKU, Austria
Flash 11 – Successful Transfer of Raman Models from Ambr®250 high-throughput systems to larger Scale Stirred Tank Bioreactors
Jens Traenkle, Bayer, Germany
Flash 12 – Modular mini-factories for the automated and scalable production of ATMPs
Andreas Traube, Fraunhofer, Germany
Flash 13 – Rapid assessment of Aggregation of Biologics in different matrices and from Upstream and Downstream Development Process Stages
Aris Perrou, PAIA Biotech GmbH, Germany12:30 - 14:30 Lunch at Lunch Hall
Dessert and coffee (will be served at Exhibition Hall)14:30 - 16:00 Poster Session II (at Exhibition Hall) 16:00 – 17:30 Scientific Session: Challenges and Marvels of Bioprocess Intensification (part I)
Chairpersons:
Chetan Goudar, Amgen, USA
Paulo Fernandes, Orchad, Uk
Stefanos Grammatikos, UCB, Belgium
INV 9 - Process Intensification Opportunities, Challenges and Solutions: Product Quality, Harvest and Scale Up Considerations for Intensified Processes
Bassem Bem Yahia, UCB Pharma, Belgium
INV 10 - Enabling Intensified Bioprocesses At Scale
Daniel Karst, Biogen International GmbH, Switzerland
O 19 - Process intensification and connected processing for robust, cost effective, and fast manufacturing of monoclonal antibodies
Sanket Jadhav, Sartorius, Netherlands
O 20 - Overcoming product retention in TFF-based perfusion cell cultures by using low shear magnetically levitating pumps
Magdalena Pappenreiter, Bilfinger Life Science GmbH, Innovation Management; University of Natural Resources and Life Sciences (BOKU), Austria
O 21 - Migrating a months-long perfusion process to intensified fed-batch
Vicky Goralczyk, FyoniBio GmbH, Germany17:30 - 18:00 Announcement & Networking Activities 18:00 – 21:00 Social Event & Cocktail -
9:00 - 10:00 Keynote Lecture
Raymond J. Deshaies, Amgen Research, United States
Multispecificity – the future of molecular medicines10:00 - 10:30 TOP 10 Finalists - Poster Prize Flash Presentations
The 10 Top Finalists - selected during Posters sessions I and II by the jury will be invited to present their poster10:30 - 11:30 POSTER SESSION III & Coffee Break at Exhibition 11:30 – 12:30 Scientific Session: Adaptive manufacturing: engineering quality into your process (part II)
Chairpersons:
Anne Tolstrup, AbtBioConsult, Denmark
Laura Palomares, IBT-UNAM, Mexico
INV 11 - Next-generation, feedback responsive cell factories for recombinant protein manufacturing
Laura Segatori, Rice University, United States
O 22 – Identification and Control of Novel Waste Inhibitory Metabolites In CHO Cell-Cultures
Sanket Jadhav, University of Massachustts Lowell, United States
O 23 – State-of-the-art strategies for adeno-associated virus product homogeneity assessment
Marco Radukic, Biofidus AG / Bielefeld University, Germany12:30 - 14:30 Lunch at Lunch Hall
Dessert and coffee (will be served at Exhibition Hall)14:30 – 16:00 Scientific Session: Challenges and Marvels of Bioprocess Intensification (part II)
Chairpersons:
Chetan Goudar, Amgen, USA
Paulo Fernandes, Orchad, Uk
Stefanos Grammatikos, UCB, Belgium
O 24 – Optimization of continuous HIV-1 Gag virus-like particles (VLPs) harvest using an alternative perfusion approach
Jesus Lavado, Universitat Autònoma de Barcelona (UAB), Spain
O 25 – The perks of innovating influenza VLP-based vaccine production
Antonio Roldao, IBET & ITQB-NOVA, Portugal
O 26 – Cell Therapy Process Development with a 2 ml Continuous Perfusion Bioreactor
Kevin Lee, Erbi Biosystems Inc., United States
O 27 – Ultracentrifugation for AAV manufacturing: non-linear scale-up improves quality & scalability
Duarte Martins, Takeda, Austria
Flash 14 – Intensify Viral Vector Manufacturing Using Tangential Flow Depth Filtration (TFDF) platform
Rachel Legmann, Repligen corp, United States
Flash 15 – A scalable bioprocess strategy for rAAV2 production using a stable cell line system
Jose Escandell, iBET, Portugal
Flash 16 – Establishment of two suspension adapted stable packaging cell lines for scalable lentivirus production
Maximilian Klimpel, CSL Behring Innovation GmbH, Germany
Flash 17 – Integrated process for the production and purification of therapeutic mesenchymal stromal cell-derived extracellular vesicles
Ana Fernandes-Platzgummer, Instituto Superior Técnico, Univ Lisboa, Portugal16:00 - 17:00 Keynote Lecture
Robert Deans, Synthego, United States
Engineering Biology for future medicines17:30 - 18:00 ESACT Medals Ceremony
The ESACT Medals are attributed to ESACT members in recognition of their contribution to ESACT activities.
In 2022 Roland Wagner, Yvonne Genzel and Amine Kamen will be awarded with ESACT medals.
ESACT 2022 Poster Prize Announcements
CLOSING CEREMONY18:00 TRANSFER TO CONGRESS DINNER 19:00 – 22:00 CONGRESS DINNER
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